Response of Odontoblast to the Bio-Calcium Phosphate Cement
김진우, 김성원, 김규천, 김용덕, 김철훈, 김복주, 김욱규,
소속 상세정보
김진우 ( Kim Jin-Woo ) - 동아대학교 의과대학 구강악안면외과학교실
김성원 ( Kim Sung-Won ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
김규천 ( Kim Gyoo-Cheon ) - 부산대학교 치과대학 구강해부학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
김철훈 ( Kim Chul-Hoon ) - 동아대학교 의과대학 구강악안면외과학교실
김복주 ( Kim Bok-Joo ) - 동아대학교 의과대학 구강악안면외과학교실
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
KMID : 0360120110330040301
Abstract
PURPOSE: If the tooth structure is damaged, then it is impossible to regenerate the tooth. The materials used to restore the tooth structure are not related to the composition of the tooth. The materials used to restore the structure can’t replace the natural tooth because they just fill the defective structure. Calcium phosphate cement remineralizes the dentin and almost replaces the natural tooth, but there are some disadvantages. We conducted basic tests with Biomimetic CPC (Bio-CPC) to make sure of the possibility of the biomaterial to remineralize the defective tooth structure.
METHODS: In this study, the bioactivity and biocompatibility of Bio-CPC were evaluated for its potential value as the bio-material for regeneration of damaged tooth structure by conducting a cell toxicity assay (WST-1 assay), a cytokinesis-block micronucleus assay, a chromosomal aberration test, total RNA extraction and RT-PCR on MDPC-23 mouse odontoblast-like cells.
RESULTS:The in vitro cytotoxicity test showed that the Bio-CPC was fairly cytocompatible for the MDPC-23 mouse odontoblast-like cells.
CONCLUSION: Bio-CPC has a possibility to be a new biomaterial and further study of Bio-CPC is needed.
키워드
Calcium phosphate cement; CPC; Odontoblast
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